PATENT

Patent Abstract

Method and System for Class-I Peptide-MHC Structural Normalization and Wild-Type-Relative Mutation Tracking

Patent application 202641034620 in the Manish KL patent portfolio, covering computational structural biology and related technical systems.

202641034620 2026-03-23 Computational Structural Biology
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Summary

Overview

A deterministic structural normalization pipeline converts peptide-MHC class I structure files into stable wild-type-relative mutation fingerprints for downstream computational analysis.

Abstract

Technical Abstract

Wild-type and mutant structures are parsed into residue-level chains, assigned fixed semantic roles, and transformed into peptide-to-heavy-chain contact records under explicit distance criteria. The system computes a normalized delta relative to wild type and serializes a machine-readable fingerprint object containing mutation identity, chain mapping status, and contact-derived fields.

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peptide MHC patent, structural normalization patent, mutation tracking patent, computational biology patent, structural fingerprint patent

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